My opinion: yes, they can hold up...but an inexperienced or non-careful driver can break them easily. Hell, if you're abusive you can break stuff with the factory tires still on...much less larger ones. Someone that's careful, picks their lines instead of gassing it up straight ahead, and knows when to back down...sure, I think they'd last quite a while. There'll be wear and tear, but that's going to happen anyway...the rate just depends on the tire size and the driver's habits. With all that said, I'll have alloy shafts in mine before I go to 37's. Probably Superiors in the rear, RCV's in the front.
Remember, big tires aren't just rough on the axles...there are other things in play, too...