A carburetor uses vacuum both as a signal and as power to meter the gas. If you have too big a venturi, the vacuum will be low and fuel metering will be poor. You can still make the big carburetor work by setting it up rich, so that the engine always has enough fuel.
I'd skip the 4V entirely and go with the aluminum Jeep 2V manifold. Either the Motorcraft 2100 2V or the Weber 2V work well with this manifold. The Weber comes in a 32/36 progressive type, that is like half a 4V in function. It also comes in a 38/38 non-progressive model, for higher performance and less economy. A throttle body from a 4.3L Chevy V6 also works well, but you'll need the rest the stuff to support TBI.
1) '77 J10 LWB, 258/T15/D20/3.54 bone stock, low options (delete radio), PS, hubcaps. 2) '82 J20 360/T18/NP208/3.73, KOs, 7600 GVWR 3) '75 CJ-6, 304/T15, PS, BFG KM2s, soft top 4) '95 VW Golf Sport 2000cc 2D