Depends! What axles, have you ever pulled your axle shafts before, do you have experience with bleeding brake systems and are you changing master cylinder, proportioning valve etc.
I did one on a Dana 44 out of a scout and the biggest problem I had was getting the hydroboost system I installed at the same time, dialed in. The actual install of the brackets, rotors and calipers is pretty straight forward. I had to grind down some spacers to get the calipers to run true over the rotors. I have heard some guys having a hard time getting the cadillac calipers to bleed properly, but I did not run into that problem, fortunately.