I recently watched a video with ER surgeon talking about gun wonds. It really has opened my eyes about this.
Bottom line is it seems cavitations and penetration are what is likely to kill quickly. The higher the bullet speed the more internal damage, the deeper the penetration the more likely to hit a vital organ. A big hole (from hollow points) will make somebody bleed out, but if it doesn't penetrate deep enough that is a slower death. Hitting a vital organ stops them quicker then bleeding to death. A bad guy is no longer a threat when he is dead. Guns are for killing, if you want to incapacitate use pepper spray. Killing quickly stops the threat quickly. Stopping the threat quickly should be your goal if presented with a threat that you feel you need to use deadly force against.
As far as hand guns go, from his experience hand guns are not nearly as effective as we think they might be. Rifles, when compared to hand guns, are more effective than most think they are.
After watching this video I now load every other round with jacked hollow point (more tissue damage and some penetration) and FMJ (deeper penetration).
01 TJ, 34 Super Swaper 34x10.5 bias, Winch, locked, belly up, some armor, 4.0, 5spd