US 50 goes along the Arkansas River west of Pueblo, Co. If you are into white water rafting, this would be the place. US 50 goes to the Buena Vista, Col. area. There are several fun trails in that area.
Go to: www.funtreks.com
and get the Colorado book. It will have all the trail info that you need.
A couple of suggestions:
Tin Cup Pass
You also get pretty close to the Ouray area, just south of Montrose, Col. The same book will have trails for that area, which I highly recommend.
US 50 joins I-70 at Grand Junction. You are now within an hour of Moab, Ut. Don't pass this chance up.