Originally Posted by funkduck
Well, that's certainly one
Good luck, sir!
totally agree with your statement! But to each their own...
To further answer you need to watch the impedance. Typically home or multi media speakers are 8ohm nominal. Car speakers usually run 4 ohm nominal.
Further, what channel on the amp/ head unit were you planing on using? There is a fet cap on the OE tweeter matted to its impdance etc. Honestly a full set of components with mid+tweeter along with cross over network is your best option as they are designed to work in a car. Your desk speakers are paired to the enclosure they are in to obtain that sound. Changing the enclosure will change the sonic signature.