2012 Laredo X, Q1, V6
I took a 1200 mile roundtrip about 1 month ago in a combo of good, dry and poor, snowy highway/freeway. I averaged 23.5 mpg (total miles/total gas purchased) for the trip, with a high of 25.5 mpg on one sunny leg at 65-70 mph and a low of 21 mpg at 45-65 mph on icey/snowy roads. I can see a 2 mpg difference in areas/states that require "winter gas" that contains 10% ethanol.
I have noticed the mpg goes south quickly at speeds above 70 mph.
In our area, the "cheap gas" contains 10% ethanol and you can pay 10 cents per gallon more for "super unleaded" that contains no ethanol - and come out ahead with the extra mpg.
In daily driving (50/50 city/hwy), I average 19-20 mpg in winter and 21-22 mpg in summer.