i mean your acceleration would suffer (take a hit). You have a 6cyl? More than likely, your ratio is 3.07 stock. you can look on the rear diff cover and there should be a small metal tag on two of the bolts indicating your gearing ratio. You'll pretty much loose the use of 5th gear by running 33's and it will take you a little while to climb to 60-65 on the highway.
I'd recommend going to 4.10s... or 4.56 if you want more offroad performance.
1995.5 Isuzu Rodeo - SAS'd and SOA'd, sitting on 36x12.50 TSLs, D44 front, 14bff rear, locked by OX and Detriot, suspensions by Jeep and Chevy, high steer conversion, 5.13 gearing and Teralow in the case.